SNARE protein structure and function.
Publication Year
2003
Type
Journal Article
Abstract
The SNARE superfamily has become, since its discovery approximately a decade ago, the most intensively studied element of the protein machinery involved in intracellular trafficking. Intracellular membrane fusion in eukaryotes requires SNARE (soluble N-ethylmaleimide-sensitive-factor attachment protein receptor) proteins that form complexes bridging the two membranes. Although common themes have emerged from structural and functional studies of SNAREs and other components of the eukaryotic membrane fusion machinery, there is still much to learn about how the assembly and activity of this machinery is choreographed in living cells.
Keywords
Journal
Annu Rev Cell Dev Biol
Volume
19
Pages
493-517
ISSN Number
1081-0706
Alternate Journal
Annu. Rev. Cell Dev. Biol.
PMID
14570579