Frederick Hughson

First name

Frederick

Last name

Hughson

Eisemann, Travis, Frederick Allen, Kelly Lau, Gregory Shimamura, Philip Jeffrey, and Frederick Hughson. (2020) 2020. “The Sec1 Munc18 Protein Vps45 Holds the Qa-SNARE Tlg2 in an Open Conformation”. Elife 9: e60724. doi:10.7554/eLife.60724.

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Travis, Sophie, Kevin DAmico, I-Mei Yu, Conor McMahon, Safraz Hamid, Gabriel Ramirez-Arellano, Philip Jeffrey, and Frederick Hughson. (2020) 2020. “Structural Basis for the Binding of SNAREs to the Multisubunit Tethering Complex Dsl1”. J Biol Chem 295 (30): 10125-35. doi:10.1074/jbc.RA120.013654.

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Travis, Sophie, Bashkim Kokona, Robert Fairman, and Frederick Hughson. (2019) 2019. “Roles of Singleton Tryptophan Motifs in COPI Coat Stability and Vesicle Tethering”. Proc Natl Acad Sci U S A 116 (48): 24031-40. doi:10.1073/pnas.1909697116.

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Brose, Nils, Axel Brunger, David Cafiso, Edwin Chapman, Jiajie Diao, Frederick Hughson, Meyer Jackson, et al. (2019) 2019. “Synaptic Vesicle Fusion: Today and Beyond”. Nat Struct Mol Biol 26 (8): 663-68. doi:10.1038/s41594-019-0277-z.

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Paczkowski, Jon, Amelia McCready, Jian-Ping Cong, Zhijie Li, Philip Jeffrey, Chari Smith, Brad Henke, Frederick Hughson, and Bonnie Bassler. (2019) 2019. “An Autoinducer Analogue Reveals an Alternative Mode of Ligand Binding for the LasR Quorum-Sensing Receptor”. ACS Chem Biol 14 (3): 378-89. doi:10.1021/acschembio.8b00971.

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Jiao, Junyi, Mengze He, Sarah Port, Richard Baker, Yonggang Xu, Hong Qu, Yujian Xiong, et al. (2018) 2018. “Munc18-1 Catalyzes Neuronal SNARE Assembly by Templating SNARE Association”. Elife 7: e41771. doi:10.7554/eLife.41771.

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Munson, Mary, and Frederick Hughson. (2002) 2002. “Conformational Regulation of SNARE Assembly and Disassembly in Vivo.”. J Biol Chem 277 (11): 9375-81. doi:10.1074/jbc.M111729200.

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Hughson, Frederick. (2008) 2008. “Both Layers of the COPII Coat Come into View.”. Cell 134 (3): 384-5. doi:10.1016/j.cell.2008.07.027.

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Neiditch, Matthew, and Frederick Hughson. 2007. “The Regulation of Histidine Sensor Kinase Complexes by Quorum Sensing Signal Molecules.”. Methods Enzymol 423: 250-63. doi:10.1016/S0076-6879(07)23011-3.

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Cavanaugh, Lorraine, Xiaocheng Chen, Brian Richardson, Daniel Ungar, Istvan Pelczer, Josep Rizo, and Frederick Hughson. (2007) 2007. “Structural Analysis of Conserved Oligomeric Golgi Complex Subunit 2.”. J Biol Chem 282 (32): 23418-26. doi:10.1074/jbc.M703716200.

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Neiditch, Matthew, Michael Federle, Audra Pompeani, Robert Kelly, Danielle Swem, Philip Jeffrey, Bonnie Bassler, and Frederick Hughson. (2006) 2006. “Ligand-Induced Asymmetry in Histidine Sensor Kinase Complex Regulates Quorum Sensing.”. Cell 126 (6): 1095-108. doi:10.1016/j.cell.2006.07.032.

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Ungar, Daniel, Toshihiko Oka, Monty Krieger, and Frederick Hughson. (2006) 2006. “Retrograde Transport on the COG Railway.”. Trends Cell Biol 16 (2): 113-20. doi:10.1016/j.tcb.2005.12.004.

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Ungar, Daniel, Toshihiko Oka, Eliza Vasile, Monty Krieger, and Frederick Hughson. (2005) 2005. “Subunit Architecture of the Conserved Oligomeric Golgi Complex.”. J Biol Chem 280 (38): 32729-35. doi:10.1074/jbc.M504590200.

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Neiditch, Matthew, Michael Federle, Stephen Miller, Bonnie Bassler, and Frederick Hughson. (2004) 2005. “Regulation of LuxPQ Receptor Activity by the Quorum-Sensing Signal Autoinducer-2.”. Mol Cell 18 (5): 507-18. doi:10.1016/j.molcel.2005.04.020.

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Miller, Stephen, Karina Xavier, Shawn Campagna, Michiko Taga, Martin Semmelhack, Bonnie Bassler, and Frederick Hughson. (2004) 2004. “Salmonella Typhimurium Recognizes a Chemically Distinct Form of the Bacterial Quorum-Sensing Signal AI-2.”. Mol Cell 15 (5): 677-87. doi:10.1016/j.molcel.2004.07.020.

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Ungar, Daniel, and Frederick Hughson. 2003. “SNARE Protein Structure and Function.”. Annu Rev Cell Dev Biol 19: 493-517. doi:10.1146/annurev.cellbio.19.110701.155609.

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Chen, Xin, Stephan Schauder, Noelle Potier, Alain Van Dorsselaer, István Pelczer, Bonnie Bassler, and Frederick Hughson. (2002) 2002. “Structural Identification of a Bacterial Quorum-Sensing Signal Containing Boron.”. Nature 415 (6871): 545-9. doi:10.1038/415545a.

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Yu, I-Mei, and Frederick Hughson. 2010. “Tethering Factors As Organizers of Intracellular Vesicular Traffic.”. Annu Rev Cell Dev Biol 26: 137-56. doi:10.1146/annurev.cellbio.042308.113327.

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Tripathi, Arati, Yi Ren, Philip Jeffrey, and Frederick Hughson. (2009) 2009. “Structural Characterization of Tip20p and Dsl1p, Subunits of the Dsl1p Vesicle Tethering Complex.”. Nat Struct Mol Biol 16 (2): 114-23. doi:10.1038/nsmb.1548.

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McMahon, Conor, Sean Studer, Chaevia Clendinen, Geoffrey Dann, Philip Jeffrey, and Frederick Hughson. (2012) 2012. “The Structure of Sec12 Implicates Potassium Ion Coordination in Sar1 Activation.”. J Biol Chem 287 (52): 43599-606. doi:10.1074/jbc.M112.420141.

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Chen, Guozhou, Lee Swem, Danielle Swem, Devin Stauff, Colleen O’Loughlin, Philip Jeffrey, Bonnie Bassler, and Frederick Hughson. (2011) 2011. “A Strategy for Antagonizing Quorum Sensing.”. Mol Cell 42 (2): 199-209. doi:10.1016/j.molcel.2011.04.003.

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Lees, Joshua, Calvin Yip, Thomas Walz, and Frederick Hughson. (2010) 2010. “Molecular Organization of the COG Vesicle Tethering Complex.”. Nat Struct Mol Biol 17 (11): 1292-7. doi:10.1038/nsmb.1917.

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Hughson, Frederick. (2010) 2010. “Copy Coats: COPI Mimics Clathrin and COPII.”. Cell 142 (1): 19-21. doi:10.1016/j.cell.2010.06.031.

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Hughson, Frederick, and Karin Reinisch. (2010) 2010. “Structure and Mechanism in Membrane Trafficking.”. Curr Opin Cell Biol 22 (4): 454-60. doi:10.1016/j.ceb.2010.03.011.

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Ren, Yi, Calvin Yip, Arati Tripathi, David Huie, Philip Jeffrey, Thomas Walz, and Frederick Hughson. (2009) 2009. “A Structure-Based Mechanism for Vesicle Capture by the Multisubunit Tethering Complex Dsl1.”. Cell 139 (6): 1119-29. doi:10.1016/j.cell.2009.11.002.

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Kelly, Robert, Megan Bolitho, Douglas Higgins, Wenyun Lu, Wai-Leung Ng, Philip Jeffrey, Joshua Rabinowitz, Martin Semmelhack, Frederick Hughson, and Bonnie Bassler. (2009) 2009. “The Vibrio Cholerae Quorum-Sensing Autoinducer CAI-1: Analysis of the Biosynthetic Enzyme CqsA.”. Nat Chem Biol 5 (12): 891-5. doi:10.1038/nchembio.237.

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Richardson, Brian, Richard Smith, Daniel Ungar, Ayumi Nakamura, Philip Jeffrey, Vladimir Lupashin, and Frederick Hughson. (2009) 2009. “Structural Basis for a Human Glycosylation Disorder Caused by Mutation of the COG4 Gene.”. Proc Natl Acad Sci U S A 106 (32): 13329-34. doi:10.1073/pnas.0901966106.

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Boyaci, Hande, Tayyab Shah, Amanda Hurley, Bashkim Kokona, Zhijie Li, Christian Ventocilla, Philip Jeffrey, et al. (2016) 2016. “Structure, Regulation, and Inhibition of the Quorum-Sensing Signal Integrator LuxO.”. PLoS Biol 14 (5): e1002464. doi:10.1371/journal.pbio.1002464.

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Suckling, Richard, Pak Phi Poon, Sophie Travis, Irina Majoul, Frederick Hughson, Philip Evans, Rainer Duden, and David Owen. (2015) 2015. “Structural Basis for the Binding of Tryptophan-Based Motifs by δ-COP.”. Proc Natl Acad Sci U S A 112 (46): 14242-7. doi:10.1073/pnas.1506186112.

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Baker, Richard, Philip Jeffrey, Michael Zick, Ben Phillips, William Wickner, and Frederick Hughson. (2015) 2015. “A Direct Role for the Sec1 Munc18-Family Protein Vps33 As a Template for SNARE Assembly.”. Science 349 (6252): 1111-4. doi:10.1126/science.aac7906.

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Ha, Jun Yong, Irina Pokrovskaya, Leslie Climer, Gregory Shimamura, Tetyana Kudlyk, Philip Jeffrey, Vladimir Lupashin, and Frederick Hughson. (2014) 2014. “Cog5-Cog7 Crystal Structure Reveals Interactions Essential for the Function of a Multisubunit Tethering Complex.”. Proc Natl Acad Sci U S A 111 (44): 15762-7. doi:10.1073/pnas.1414829111.

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Rogers, Jason, Conor McMahon, Anastasia Baryshnikova, Frederick Hughson, and Mark Rose. (2014) 2014. “ER-Associated Retrograde SNAREs and the Dsl1 Complex Mediate an Alternative, Sey1p-Independent Homotypic ER Fusion Pathway.”. Mol Biol Cell 25 (21): 3401-12. doi:10.1091/mbc.E14-07-1220.

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Bharucha, Nike, Yang Liu, Effrosyni Papanikou, Conor McMahon, Masatoshi Esaki, Philip Jeffrey, Frederick Hughson, and Benjamin Glick. (2013) 2013. “Sec16 Influences Transitional ER Sites by Regulating Rather Than Organizing COPII.”. Mol Biol Cell 24 (21): 3406-19. doi:10.1091/mbc.E13-04-0185.

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Baker, Richard, Philip Jeffrey, and Frederick Hughson. 2013. “Crystal Structures of the Sec1 Munc18 (SM) Protein Vps33, Alone and Bound to the Homotypic Fusion and Vacuolar Protein Sorting (HOPS) Subunit Vps16*.”. PLoS One 8 (6): e67409. doi:10.1371/journal.pone.0067409.

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Hughson, Frederick. (2013) 2013. “Neuroscience. Chaperones That SNARE Neurotransmitter Release.”. Science 339 (6118): 406-7. doi:10.1126/science.1233801.

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Ha, Jun Yong, Hui-Ting Chou, Daniel Ungar, Calvin Yip, Thomas Walz, and Frederick Hughson. (2016) 2016. “Molecular Architecture of the Complete COG Tethering Complex.”. Nat Struct Mol Biol 23 (8): 758-60. doi:10.1038/nsmb.3263.

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